Attracting about 100 members, the fifth version of our French Phages.fr annual convention was as soon as extra successful. This yr’s convention happened on the Institute for Structural Biology on the European Electron and Photon Campus in Grenoble, October eight and 9, 2019. Similar to earlier years, our assembly gathered scientists primarily working in France, from tutorial labs and hospitals in addition to from trade. We additionally had the pleasure of welcoming attendees from totally different European international locations and even past. The convention was divided into 4 classes:
Ecology and Evolution, Phage Therapy and Biotechnology, Structure and Assembly and Phage-Host Interaction, every opened by a keynote lecture. The talks, chosen from abstracts, gave the chance for younger scientists (particularly college students and post-docs) to current their undertaking and ends in a pleasant environment. Poster classes additionally favoured interactions and discussions between younger researchers and extra senior scientists. Here, we offer a abstract of the matters developed throughout the convention.
Cytoplasmic dynein-2 is a motor protein complicated that drives the motion of cargoes alongside microtubules inside cilia, facilitating the meeting of those organelles on the floor of almost all mammalian cells. Dynein-2 is essential for ciliary operate, as evidenced by deleterious mutations in sufferers with skeletal abnormalities. Long-standing questions embody how the dynein-2 complicated is assembled, regulated, and switched between lively and inactive states. A mix of mannequin organisms, in vitro cell biology, live-cell imaging, structural biology and biochemistry has superior our understanding of the dynein-2 motor. In this Cell Science at a Glance article and the accompanying poster, we talk about the present understanding of dynein-2 and its roles in ciliary meeting and performance.
Meeting Report – Workshop ‘Actin-based mechanosensation and power era in well being and illness’.
International specialists within the fields of mobile motility, power era and mechanosensation met in Baeza, a UNESCO World Heritage metropolis, from the 10th to the 13th of November, 2019. The assembly, a part of the ‘Current Trends in Biomedicine’ collection, happened on the ‘Sede Antonio Machado’, a phenomenal 17th century constructing was a convention heart of the Universidad Internacional de Andalucía (UNIA), which sponsored the occasion. Finally, we evaluation how dysregulation of intestinal membrane mucins could contribute to human illnesses, corresponding to irritation and most cancers.
The assembly was organized by Alexis Gautreau, Pekka Lappalainen and Miguel Vicente-Manzanares, with the help of the European Molecular Biology Organization (EMBO) and the Spanish-based firm IMPETUX. Fifty scientists offered current outcomes throughout the talks, posterclasses and thematic discussions. As Baeza itself served as a crossroads of medieval Christian, Moorish and Jewish cultures, the assembly introduced collectively cell biologists, biochemists, biophysicists and engineers from all over the world that offered an built-in imaginative and prescient of the position of the actin cytoskeleton, power era and mechanosensation in various physiological processes and pathologies.
Membrane mucins cowl most mucosal surfaces all through the human physique. The gut harbors complicated inhabitants of microorganisms (the microbiota) and quite a few exogenous molecules that may hurt the epithelium. In the colon, the place the microbial burden is excessive, a mucus barrier varieties the primary line of protection by preserving micro organism away from the epithelial cells. In the small gut the place the mucus layer is much less organized, microbes are stored at bay by peristalsis and antimicrobial peptides. Additionally, a dense glycocalyx consisting of prolonged and closely glycosylated membrane mucins covers the floor of enterocytes.
Whereas many facets of mucosal limitations are being found, the operate of membrane mucins stays a largely neglected subject, primarily as a result of we lack the mandatory reagents and experimental animal fashions to research these giant glycoproteins. In this Cell Science at a Glance article and accompanying poster, we spotlight central ideas of membrane mucin biology and the position of membrane mucins as integral parts of intestinal mucosal limitations. We additionally current the present consensus regarding the position of membrane mucins in host-microbe interactions. Moreover, we talk about how regulatory circuits that govern membrane mucins within the wholesome intestine show robust overlap with pathways which are perturbed throughout persistent irritation.
Scientists from 12 international locations met on the International Mammalian Genome Conference (IMGC) to share advances in mammalian genetics and genomics analysis. The occasion was held in Strasbourg, France and represents town’s second time internet hosting the IMGC. A various attendance of pre-doctoral and post-doctoral trainees, younger investigators, established researchers, clinicians, bioinformaticians, and computational biologists loved a wealthy scientific program of 63 oral shows, 65 posters, and 5 workshops within the fields of epigenetics, system genetics, developmental biology, most cancers, human illness modeling, technical advances, and bioinformatics. This report presents chosen highlights of this assembly which illustrate how current advances in mammalian genetic approaches have improved our capacity to decipher complicated organic mechanisms.
The Bioinformatics Open Source Conference is a volunteer-organized assembly that covers open supply software program growth and open science in bioinformatics. Launched in 2000, BOSC has been held yearly since. BOSC 2019, the 20th annual BOSC, happened as one of many Communities of Special Interest (COSIs) on the Intelligent Systems for Molecular Biology assembly (ISMB/ECCB 2019). The two-day assembly included a complete of 46 talks and 55 posters, in addition to eight Birds of a Feather curiosity teams. The keynote speaker was University of Cape Town professor Dr. Nicola Mulder, who spoke on “Building infrastructure for accountable open science in Africa”. Immediately after BOSC 2019, about 50 folks participated within the two-day CollaborationFest (CoFest for brief), an open and free community-driven occasion at which members work collectively to contribute to bioinformatics software program, documentation, coaching supplies, and use circumstances.
