"French Phage Network" Annual Conference-Fifth Meeting Report.

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    “French Phage Network” Annual Conference-Fifth Meeting Report.

    Attracting about 100 members, the fifth version of our French Phages.fr annual convention was as soon as extra successful. This yr’s convention happened on the Institute for Structural Biology on the European Electron and Photon Campus in Grenoble, October eight and 9, 2019. Similar to earlier years, our assembly gathered scientists primarily working in France, from tutorial labs and hospitals in addition to from trade. We additionally had the pleasure of welcoming attendees from totally different European international locations and even past. The convention was divided into 4 classes:

    Ecology and Evolution, Phage Therapy and Biotechnology, Structure and Assembly and Phage-Host Interaction, every opened by a keynote lecture. The talks, chosen from abstracts, gave the chance for younger scientists (particularly college students and post-docs) to current their undertaking and ends in a pleasant environment. Poster classes additionally favoured interactions and discussions between younger researchers and extra senior scientists. Here, we offer a abstract of the matters developed throughout the convention.

    Cytoplasmic dynein-2 is a motor protein complicated that drives the motion of cargoes alongside microtubules inside cilia, facilitating the meeting of those organelles on the floor of almost all mammalian cells. Dynein-2 is essential for ciliary operate, as evidenced by deleterious mutations in sufferers with skeletal abnormalities. Long-standing questions embody how the dynein-2 complicated is assembled, regulated, and switched between lively and inactive states. A mix of mannequin organisms, in vitro cell biology, live-cell imaging, structural biology and biochemistry has superior our understanding of the dynein-2 motor. In this Cell Science at a Glance article and the accompanying poster, we talk about the present understanding of dynein-2 and its roles in ciliary meeting and performance.

    Meeting Report – Workshop ‘Actin-based mechanosensation and power era in well being and illness’.

    International specialists within the fields of mobile motility, power era and mechanosensation met in Baeza, a UNESCO World Heritage metropolis, from the 10th to the 13th of November, 2019. The assembly, a part of the ‘Current Trends in Biomedicine’ collection, happened on the ‘Sede Antonio Machado’, a phenomenal 17th century constructing was a convention heart of the Universidad Internacional de Andalucía (UNIA), which sponsored the occasion. Finally, we evaluation how dysregulation of intestinal membrane mucins could contribute to human illnesses, corresponding to irritation and most cancers.

    The assembly was organized by Alexis Gautreau, Pekka Lappalainen and Miguel Vicente-Manzanares, with the help of the European Molecular Biology Organization (EMBO) and the Spanish-based firm IMPETUX. Fifty scientists offered current outcomes throughout the talks, poster classes and thematic discussions. As Baeza itself served as a crossroads of medieval Christian, Moorish and Jewish cultures, the assembly introduced collectively cell biologists, biochemists, biophysicists and engineers from all over the world that offered an built-in imaginative and prescient of the position of the actin cytoskeleton, power era and mechanosensation in various physiological processes and pathologies.

    Membrane mucins cowl most mucosal surfaces all through the human physique. The gut harbors complicated inhabitants of microorganisms (the microbiota) and quite a few exogenous molecules that may hurt the epithelium. In the colon, the place the microbial burden is excessive, a mucus barrier varieties the primary line of protection by preserving micro organism away from the epithelial cells. In the small gut the place the mucus layer is much less organized, microbes are stored at bay by peristalsis and antimicrobial peptides. Additionally, a dense glycocalyx consisting of prolonged and closely glycosylated membrane mucins covers the floor of enterocytes.

    Whereas many facets of mucosal limitations are being found, the operate of membrane mucins stays a largely neglected subject, primarily as a result of we lack the mandatory reagents and experimental animal fashions to research these giant glycoproteins. In this Cell Science at a Glance article and accompanying poster, we spotlight central ideas of membrane mucin biology and the position of membrane mucins as integral parts of intestinal mucosal limitations. We additionally current the present consensus regarding the position of membrane mucins in host-microbe interactions. Moreover, we talk about how regulatory circuits that govern membrane mucins within the wholesome intestine show robust overlap with pathways which are perturbed throughout persistent irritation.

     "French Phage Network" Annual Conference-Fifth Meeting Report.

    33rd worldwide mammalian genome convention: assembly highlights.

    Scientists from 12 international locations met on the International Mammalian Genome Conference (IMGC) to share advances in mammalian genetics and genomics analysis. The occasion was held in Strasbourg, France and represents town’s second time internet hosting the IMGC. A various attendance of pre-doctoral and post-doctoral trainees, younger investigators, established researchers, clinicians, bioinformaticians, and computational biologists loved a wealthy scientific program of 63 oral shows, 65 posters, and 5 workshops within the fields of epigenetics, system genetics, developmental biology, most cancers, human illness modeling, technical advances, and bioinformatics. This report presents chosen highlights of this assembly which illustrate how current advances in mammalian genetic approaches have improved our capacity to decipher complicated organic mechanisms.

    Triton® X-100 Detergent

    B2394-100
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    100 mM Triton X-100

    603 100 ml
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    TritonX-100 (Molecular Biology Grade)

    CE240 500 ml
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    TritonX-100 (Molecular Biology Grade)

    CE241 1 l
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    Triton X-100, T-Octylphenoxypolyethoxyethanol

    CH061 1L (2 x 500ml)
    EUR 120

    Triton X-100, T-Octylphenoxypolyethoxyethanol

    CH062 4.0 L
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    Triton® X-100 Detergent

    B2394-1L
    EUR 262

    Triton® X-100 Detergent

    B2394-500
    EUR 196

    Triton® X-100, MegaPure? Detergent, 10% Solution

    2124-100
    EUR 191

    Triton® X-100 Solution (10% in H?O)

    2104-100
    EUR 137

    Urea, suitable for molecular biology

    GE1210-1KG 1 kg
    EUR 89

    Urea, suitable for molecular biology

    GE1210-500G 500 g
    EUR 64

    Tween 20, Molecular Biology Grade

    T9100-100 1L
    EUR 134

    Triton X-100, 10% solution in water

    GC7458-100ML 100 ml
    EUR 46

    Triton X-100, 10% solution in water

    GC7458-1L 1 l
    EUR 94

    Triton X-100, 10% solution in water

    GC7458-250ML 250 ml
    EUR 58

    Triton X-100, 10% solution in water

    GC7458-500ML 500 ml
    EUR 70

    Sucrose, GlenBiol, suitable for molecular biology

    GC3201-1KG 1 kg
    EUR 75

    Triton® X-100, MegaPure? Detergent, 10% Solution

    2124-1000 Ask for price

    Triton® X-100, MegaPure? Detergent, 10% Solution

    2124-50
    EUR 137

    Triton® X-100, MegaPure? Detergent, 10% Solution

    2124-500
    EUR 686

    Triton® X-100, MegaPure? Detergent, 10% Solution

    2124-set
    EUR 175

    Agarose LE, Ultra-Pure Molecular Biology Grade, 100 g

    41028-100G 100G
    EUR 222
    Description: Minimum order quantity: 1 unit of 100G

    Triton X-114

    TDB0554 500ml
    EUR 65.44

    Triton X-405

    TS4449 100ml
    EUR 71.75

    BCIP (Molecular Biology Grade)

    CE108 250 mg
    EUR 63

    BCIP (Molecular Biology Grade)

    CE109 1 g
    EUR 90

    CHAPS (Molecular Biology Grade)

    CE114 1 g
    EUR 55

    CHAPS (Molecular Biology Grade)

    CE115 5 g
    EUR 131

    CHAPS (Molecular Biology Grade)

    CE116 25 g
    EUR 410

    DAPI (Molecular Biology Grade)

    CE117 5 mg
    EUR 60

    DAPI (Molecular Biology Grade)

    CE118 25 mg
    EUR 133

    DAPI (Molecular Biology Grade)

    CE119 100 mg
    EUR 319

    Dimethylsulfoxide (Molecular Biology Grade)

    CE120 100 ml
    EUR 55

    Dimethylsulfoxide (Molecular Biology Grade)

    CE121 500 ml
    EUR 92

    DTT (Molecular Biology Grade)

    CE131 5 g
    EUR 78

    DTT (Molecular Biology Grade)

    CE132 10 g
    EUR 111

    DTT (Molecular Biology Grade)

    CE133 25 g
    EUR 203

    Glycine (Molecular Biology Grade)

    CE158 1 kg
    EUR 70

    Glycine (Molecular Biology Grade)

    CE159 5 kg
    EUR 190

    HEPES (Molecular Biology Grade)

    CE171 100 g
    EUR 82

    HEPES (Molecular Biology Grade)

    CE172 500 g
    EUR 224

    HEPES (Molecular Biology Grade)

    CE173 1 kg
    EUR 354

    Lysozyme (Molecular Biology Grade)

    CE188 1 g
    EUR 59

    Lysozyme (Molecular Biology Grade)

    CE189 10 g
    EUR 206

    NAD (Molecular Biology Grade)

    CE196 1 g
    EUR 60

    NAD (Molecular Biology Grade)

    CE197 5 g
    EUR 138

    NBT (Molecular Biology Grade)

    CE209 1 g
    EUR 103

    NBT (Molecular Biology Grade)

    CE210 5 g
    EUR 300

    Tris (Molecular Biology Grade)

    CE237 500 g
    EUR 89

    Tris (Molecular Biology Grade)

    CE238 1 kg
    EUR 128

    Tris (Molecular Biology Grade)

    CE239 5 kg
    EUR 446

    Tween20 (Molecular Biology Grade)

    CE242 1 l
    EUR 89

    Water (Molecular Biology Grade)

    CE243 500 ml
    EUR 52

    Water (Molecular Biology Grade)

    CE244 1 l
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    Triton ® X-114 (10%) Solution

    B1015-100
    EUR 126

    Ammonium sulfate (Molecular Biology Grade)

    CE105 250 g
    EUR 46

    Ammonium sulfate (Molecular Biology Grade)

    CE106 1 kg
    EUR 60

    Ammonium sulfate (Molecular Biology Grade)

    CE107 5 kg
    EUR 128

    Bis-Acrylamid (Molecular Biology Grade)

    CE110 50 g
    EUR 79

    Bis-Acrylamid (Molecular Biology Grade)

    CE111 250 g
    EUR 216

    Formamide deionized (Molecular Biology Grade)

    CE145 500 ml
    EUR 73

    Formamide deionized (Molecular Biology Grade)

    CE146 1 l
    EUR 100

    Glycerol 87 % (Molecular Biology Grade)

    CE154 1 l
    EUR 78

    Glycerol waterfree (Molecular Biology Grade)

    CE155 500 ml
    EUR 65

    Glycerol waterfree (Molecular Biology Grade)

    CE156 1 l
    EUR 85

    Glycerol waterfree (Molecular Biology Grade)

    CE157 2.5 l
    EUR 142

    Guanidine - Hydrochloride (Molecular Biology Grade)

    CE160 100 g
    EUR 78

    Guanidine - Hydrochloride (Molecular Biology Grade)

    CE161 250 g
    EUR 128

    Guanidine - Hydrochloride (Molecular Biology Grade)

    CE162 500 g
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    Guanidine - Hydrochloride (Molecular Biology Grade)

    CE163 1 kg
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    Guanidine Thiocyanate (Molecular Biology Grade)

    CE164 100 g
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    Guanidine Thiocyanate (Molecular Biology Grade)

    CE165 500 g
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    Guanidine Thiocyanate (Molecular Biology Grade)

    CE166 1 kg
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    Urea Crystalline (Molecular Biology Grade)

    CE167 1 kg
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    Urea Crystalline (Molecular Biology Grade)

    CE168 5 kg
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    MOPS buffer (Molecular Biology Grade)

    CE194 100 g
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    MOPS buffer (Molecular Biology Grade)

    CE195 250 g
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    Sodium chloride (Molecular Biology Grade)

    CE205 500 g
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    Sodium chloride (Molecular Biology Grade)

    CE206 1 kg
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    Sodium chloride (Molecular Biology Grade)

    CE207 5 kg
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    D(+)-Sucrose (Molecular Biology Grade)

    CE224 500 g
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    D(+)-Sucrose (Molecular Biology Grade)

    CE225 1 kg
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    D(+)-Sucrose (Molecular Biology Grade)

    CE226 5 kg
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    Tris - Hydrochloride (Molecular Biology Grade)

    CE234 250 g
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    Tris - Hydrochloride (Molecular Biology Grade)

    CE235 500 g
    EUR 120

    Tris - Hydrochloride (Molecular Biology Grade)

    CE236 1 kg
    EUR 186

    Tween 20, Molecular Biology Grade

    T9100-010 100ml
    EUR 72

    Tween 20, Molecular Biology Grade

    T9100-050 500ml
    EUR 111

    Water, Ultrapure Molecular Biology Grade

    41024-4L 4L
    EUR 121
    Description: Minimum order quantity: 1 unit of 4L

    Phenol, (Carbolic acid) Double distilled for Molecular Biology

    PD0252 500g
    EUR 160.49

    Agarose, low EEO, GlenBiol, suitable for molecular biology

    GE6258-100G 100 g
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    The Bioinformatics Open Source Conference is a volunteer-organized assembly that covers open supply software program growth and open science in bioinformatics. Launched in 2000, BOSC has been held yearly since. BOSC 2019, the 20th annual BOSC, happened as one of many Communities of Special Interest (COSIs) on the Intelligent Systems for Molecular Biology assembly (ISMB/ECCB 2019). The two-day assembly included a complete of 46 talks and 55 posters, in addition to eight Birds of a Feather curiosity teams. The keynote speaker was University of Cape Town professor Dr. Nicola Mulder, who spoke on “Building infrastructure for accountable open science in Africa”. Immediately after BOSC 2019, about 50 folks participated within the two-day CollaborationFest (CoFest for brief), an open and free community-driven occasion at which members work collectively to contribute to bioinformatics software program, documentation, coaching supplies, and use circumstances.